The MCC Theatre, a renowned off-Broadway venue, was founded by LuPone, who also happened to be Legend Patti LuPone's brother.
The Pajama Game, starring Liza Minnelli, was his first professional gig, and it was at the Westbury Music Fair.
Following his 1968 Juilliard BFA in Dance graduation, he made his Broadway debut in Noel Coward's Sweet Potato.
After appearing in musicals for more than a decade, LuPone eventually stopped dancing and focused more on developing his acting abilities.
LuPone was raised on Long Island along with his siblings after being born in Brooklyn, New York. His father was an English teacher and the principal of Walt Whitman High School in Huntington, and his mother was a librarian at the C.W. Post Campus of Long Island University.
He is survived by his wife, Virginia, his son Orlando, his sister Patti and his brother William.